The Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS) has successfully performed a haplo-identical bone marrow transplant on a five-year-old boy suffering from X-linked Adrenoleukodystrophy (X-ALD), a rare inherited genetic disorder that mainly affects young boys and damages the brain, spinal cord and adrenal glands. The life-saving procedure was made possible after the child’s father donated stem cells, SGPGIMS said on Sunday.
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Dr Sayan Sinha Roy, assistant professor in the department of hematology, said hematopoietic stem cell transplantation (HSCT), commonly known as a bone marrow transplant, is “currently the only established treatment capable of stopping the progression of X-ALD,” provided it is performed before permanent neurological damage occurs.
The transplant was led by Dr Rajesh Kashyap, head of the department of hematology, with support from experts in hematology, medical genetics and laboratory medicine.
SGPGIMS director Dr R K Dhiman said the achievement reflects the institute’s commitment to advanced research and multidisciplinary care, adding that it offers hope to families battling rare genetic diseases and improves access to advanced treatment in North India.
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Conducted under the National Programme for Rare Diseases (NPRD), the transplant is SGPGIMS’s first successful bone marrow transplant for X-ALD and, according to the institute, the first such successful procedure in North India.
A haplo-identical transplant is a bone marrow or stem cell transplant using a half-matched family donor, usually a parent, when a fully matched donor is unavailable.
