New Delhi, Most people worldwide could be categorised as having a high genetic risk for three of 28 common conditions, including diabetes, cardiovascular disease and schizophrenia, even if they might not develop them, a new study has found.
Researchers, led by the UK’s University of Exeter, described the ‘average’ human genome, finding that everyone, regardless of their current health status, could be considered at risk for numerous conditions based on their genetics alone. The team analysed data from two major population biobanks the UK Biobank and the US’ All of Us that include whole genome sequencing, covering nearly one million individuals. “Yet most people are unaware of just how much genetic variation is present in every genome. Actually, variation is the norm.
For the first time, our study outlines what to expect in the average human genome, which can benefit clinicians and patients across the word in understanding, interpreting and contextualising genomics,” Wright said.
Our findings also provide important context for professionals who are interpreting genetic testing results or commissioning genetic screening programmes. participation is skewed towards people of Western European origin, and the researchers acknowledged the need for data from more diverse populations to further improve understanding and impact Although the studies are large. The senior author added, “It is therefore crucial to consider context when interpreting findings from genetic testing, including symptoms or family history of disease as well as other clinical and environmental risk factors.
